Mårtensson J, Larsson J, Nordström H
Eur J Clin Invest. 1987 Apr;17(2):130-5. doi: 10.1111/j.1365-2362.1987.tb02392.x.
Owing to the high content of cyst(e)ine and sulphated mucopolysaccharides in skin tissues, an increased demand for sulphur amino acids could be expected during the anabolic phase in severely burned patients. As a marker for sulphur amino acid deficiency, leucocyte glutathione, methionine and taurine concentrations and urinary excretion of sulphur amino acids and inorganic sulphate were followed in five severely burned patients during a 5-month period (1-6 months post injury). Reduced leucocyte concentrations of glutathione, methionine and taurine, and decreased urinary excretion of inorganic sulphate, methionine, cyst(e)ine and taurine were observed, and were most pronounced 2 or 3 months after injury. Simultaneously a minor decrease in urinary output and leucocyte concentration of branched-chain amino acids and serine were also found, whereas normal levels of glycine, threonine, and glutamine were registered. The episode of limited availability of sulphur amino acids coincides with the period of most intensive collagen and keratin resynthesis of burned skin tissue.
由于皮肤组织中胱氨酸和硫酸化粘多糖含量较高，预计严重烧伤患者在合成代谢阶段对含硫氨基酸的需求会增加。作为含硫氨基酸缺乏的标志物，在5名严重烧伤患者伤后5个月期间（伤后1 - 6个月），对白细胞谷胱甘肽、蛋氨酸和牛磺酸浓度以及含硫氨基酸和无机硫酸盐的尿排泄情况进行了跟踪。观察到白细胞谷胱甘肽、蛋氨酸和牛磺酸浓度降低，无机硫酸盐、蛋氨酸、胱氨酸和牛磺酸的尿排泄减少，且在伤后2或3个月最为明显。同时还发现尿量略有减少，白细胞中支链氨基酸和丝氨酸浓度降低，而甘氨酸、苏氨酸和谷氨酰胺水平正常。含硫氨基酸供应受限的阶段与烧伤皮肤组织中胶原蛋白和角蛋白最活跃的再合成时期相吻合。
