依托咪酯对卵巢甾体激素生成的影响。

Effects of etomidate on ovarian steroidogenesis.

作者信息

Heytens L, Devroey P, Camu F, Van Steirteghem A C

出版信息

Hum Reprod. 1987 Feb;2(2):85-90. doi: 10.1093/oxfordjournals.humrep.a136506.

DOI:10.1093/oxfordjournals.humrep.a136506

Abstract

The present study investigated the influence of two i.v. induction agents, etomidate (0.25 mg/kg) and thiopental (4 mg/kg) followed by isofluorane anaesthesia on the venous blood concentrations of prolactin (PRL), follicle-stimulating hormone (FSH), 17 beta-oestradiol (E2), progesterone (P), 17OH-progesterone (17OH-P) and testosterone (T) in 18 patients during laparoscopy for oocyte aspiration for in-vitro fertilization. A sharp decrease in the plasma concentration of E2 (P less than 0.01), P (P less than 0.01), 17OH-P (P less than 0.01) and T (P less than 0.01) was observed within 10 min after induction of anaesthesia with etomidate, followed by a gradual return to the baseline levels thereafter. No such decrease was noted after the administration of thiopental. These findings suggest that etomidate, which has previously been reported to inhibit adrenocortical steroidogenesis, can also interfere with the endocrine function of the ovary.

摘要

本研究调查了两种静脉诱导药物依托咪酯（0.25mg/kg）和硫喷妥钠（4mg/kg），继以异氟烷麻醉，对18例因体外受精进行腹腔镜取卵术患者静脉血中催乳素（PRL）、促卵泡激素（FSH）、17β-雌二醇（E2）、孕酮（P）、17-羟孕酮（17OH-P）和睾酮（T）浓度的影响。依托咪酯麻醉诱导后10分钟内，观察到E2（P<0.01）、P（P<0.01）、17OH-P（P<0.01）和T（P<0.01）的血浆浓度急剧下降，此后逐渐恢复至基线水平。硫喷妥钠给药后未观察到此类下降。这些发现表明，先前报道可抑制肾上腺皮质类固醇生成的依托咪酯，也可干扰卵巢的内分泌功能。