He Silu, Hao Xiyuan
Shenyang Pharmaceutical University, Shenhe District, Liaoning, China.
Medicine (Baltimore). 2019 May;98(19):e15284. doi: 10.1097/MD.0000000000015284.
To evaluate the effect of vitamin D3 on blood pressure in people with vitamin D deficiency.
Randomized controlled trials (RCTs) were electronically searched databases including CNKI, VIP, WanFang Data, the Cochrane Library, PubMed, and EMbase which were about oral vitamin D3 among people with vitamin D deficiency from inception to December 2017. Two reviewers independently screened literature according to the inclusion and extracted data; meta-analysis was performed using RevMan5.3.
A total of 17 RCTs with 22 arms involving 1687 participants were included. The results of meta-analysis showed that, there were no significant differences between the vitamin D deficiency group and the control group on the level of change in systolic pressure (ΔSBP) [weighted mean difference (WMD) = -1.94, 95% confidence interval (CI) (-3.93,0.04) P = .06] and on the level of change in diastolic pressure (ΔDBP) [WMD = -0.50, 95% CI (-1.17, 0.17) P = .14]. The results of subgroups showed that, there were statistically significant differences in the age of >50 years subgroup on ΔSBP [WMD = -2.32, 95% CI (-4.39, -0.25) P = .03]; there were statistically significant differences in the hypertension subgroup on ΔSBP [WMD = -6.58, 95% CI (-8.72, -4.44) P <.00001]; there were statistically significant differences in the hypertension subgroup on ΔDBP [WMD = -3.07, 95% CI (-4.66, -1.48) P = .0002]; there were statistically significant differences in the body mass index (BMI) >30 subgroup on ΔSBP [WMD = -3.51, 95% CI (-5.96, -1.07) P = .005].
Oral vitamin D3 has no significant effect on blood pressure in people with vitamin D deficiency. It reduces systolic blood pressure in people with vitamin D deficiency that was older than 50 years old or obese. It reduces systolic blood pressure and diastolic pressure in people with both vitamin D deficiency and hypertension.
评估维生素D3对维生素D缺乏人群血压的影响。
通过电子检索中国知网、维普、万方数据、考克兰图书馆、PubMed及EMbase等数据库中关于维生素D缺乏人群口服维生素D3的随机对照试验（RCT），检索时间从建库至2017年12月。两名研究者独立按照纳入标准筛选文献并提取数据；采用RevMan5.3软件进行荟萃分析。
共纳入17项RCT，涉及22个研究组，1687名参与者。荟萃分析结果显示，维生素D缺乏组与对照组在收缩压变化水平（ΔSBP）[加权均数差（WMD）=-1.94，95%置信区间（CI）（-3.93，0.04），P=0.06]和舒张压变化水平（ΔDBP）[WMD=-0.50，95%CI（-1.17,0.17），P=0.14]方面无显著差异。亚组分析结果显示，年龄>50岁亚组在ΔSBP方面有统计学显著差异[WMD=-2.32，95%CI（-4.39，-0.25），P=0.03]；高血压亚组在ΔSBP方面有统计学显著差异[WMD=-6.58，95%CI（-8.72，-4.44），P<0.00001]；高血压亚组在ΔDBP方面有统计学显著差异[WMD=-3.07，95%CI（-4.66，-1.48），P=0.0002]；体重指数（BMI）>30亚组在ΔSBP方面有统计学显著差异[WMD=-3.51，95%CI（-5.96，-1.07），P=0.005]。
口服维生素D3对维生素D缺乏人群血压无显著影响。它可降低年龄大于50岁或肥胖的维生素D缺乏人群的收缩压。它可降低维生素D缺乏合并高血压人群的收缩压和舒张压。
