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Control of oral anticoagulant treatment by chromogenic prothrombin assay.

作者信息

O'Donnell J R, Walker I D, Davidson J F

出版信息

J Clin Pathol. 1987 May;40(5):500-4. doi: 10.1136/jcp.40.5.500.

Abstract

Doses of oral anticoagulants in 50 patients on long term treatment were easily and satisfactorily monitored over six months by an automated chromogenic assay of prothrombin (CPA). It is suggested that chromogenic assay of one or more of the vitamin K dependent coagulation factors would provide a readily standardised alternative to those conventional tests which depend on human brain derived reagents, now regarded as a biohazard.

摘要

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本文引用的文献

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Turnover of prothrombin, factor VII and factor IX in a patient with hemophilia A.
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Evaluation of an automated prothrombin assay using a chromogenic substrate.
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Standardisation of oral anticoagulant treatment.
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Determination of plasma prothrombin with a reaction rate analyzer using a synthetic substrate.
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Therapeutic ranges in anticoagulant administration.
Br Med J (Clin Res Ed). 1985 Jun 8;290(6483):1683-6. doi: 10.1136/bmj.290.6483.1683.
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Creutzfeldt-Jakob disease pathogen in growth hormone preparations is eliminatable.
Lancet. 1985 Dec 7;2(8467):1299-300. doi: 10.1016/s0140-6736(85)91576-4.

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