Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Southeast Asian Food & Agriculture Science & Technology (SEAFAST) Center, Bogor Agricultural University, Bogor 16680, Indonesia.
Int J Mol Sci. 2019 May 10;20(9):2320. doi: 10.3390/ijms20092320.
Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NFκB signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NFκB activation that can lead to numerous diseases.
香叶基香叶醇（GGOH），一种存在于植物中的天然异戊二烯，具有通过抑制核因子-κB（NFκB）的激活来发挥抗炎作用。然而，其详细的作用机制尚未阐明。最近的研究表明，异戊二烯可以调节先天免疫反应中的信号分子。我们发现 GGOH 可降低脂多糖（LPS）诱导的人巨噬细胞样 THP-1 细胞中炎症基因的表达。此外，我们观察到在 LPS 刺激之前，GGOH 处理的细胞中 NFκB 信号蛋白，特别是白细胞介素-1 受体相关激酶 1（IRAK1）和肿瘤坏死因子受体相关因子 6（TRAF6）的抑制，表明存在免疫调节作用。这些结果表明 GGOH 可能调节并有助于防止过度的 NFκB 激活，从而导致许多疾病。
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