关于[具体基因名称1]和[具体基因名称2]基因表达与多发性硬化症疾病严重程度之间相关性的研究。 需注意，原文中“and”前后的基因名称缺失，以上是补充完整后的翻译内容，你可根据实际情况进行调整。
The investigation of relevancy between and gene expression and disease severity of multiple sclerosis.
作者信息
Kouchaki Ebrahim, Nikoueinejad Hassan, Akbari Hossein, Azimi Shirin, Behnam Mohammad
机构信息
a Physiology Research Center , Kashan University of Medical Sciences , Kashan , Iran.
b Department of Neurology , Kashan University of Medical Sciences , Kashan , Iran.
出版信息
J Immunoassay Immunochem. 2019;40(4):396-406. doi: 10.1080/15321819.2019.1613244. Epub 2019 May 13.
: and (protein inhibitor of activated STAT 1,2) play key roles in the pathogenesis of autoimmune and inflammatory diseases. This study aims to evaluate the gene expression of these factors in multiple sclerosis (MS) patients compared to healthy individuals and correlate them with the severity of MS. : Sixty participants, including 30 patients with MS and 30 healthy controls were studied. The expression of and genes in peripheral blood samples of all participants was measured by real-time PCR. The severity of MS was evaluated using the Expanded Disability Status Scale (EDSS). Finally, we evaluated the correlation between the expression of and genes with disease severity. : The expression of gene was increased in patients with MS compared to healthy subjects ( value<.001). Also, there was a significant correlation between the expression of and genes with disease severity according to EDSS. : Our study suggests the expression of and genes as a prognostic and diagnostic marker in MS disease.
（活化STAT 1,2的蛋白抑制剂）在自身免疫性和炎性疾病的发病机制中起关键作用。本研究旨在评估与健康个体相比，这些因子在多发性硬化症（MS）患者中的基因表达，并将它们与MS的严重程度相关联。：研究了60名参与者，包括30名MS患者和30名健康对照。通过实时PCR测量所有参与者外周血样本中基因的表达。使用扩展残疾状态量表（EDSS）评估MS的严重程度。最后，我们评估了基因表达与疾病严重程度之间的相关性。：与健康受试者相比，MS患者中基因的表达增加（值<.001）。此外，根据EDSS，基因表达与疾病严重程度之间存在显著相关性。：我们的研究表明基因的表达可作为MS疾病的预后和诊断标志物。
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