Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Mol Neurosci. 2021 Oct;71(10):2053-2059. doi: 10.1007/s12031-021-01834-6. Epub 2021 Mar 24.
Migraine is a complex disabling condition which is associated with dysregulation of several pathways particularly those being associated with immune responses. In order to assess contribution of protein inhibitor of activated STAT (PIAS) in the pathogenesis of migraine, we quantified expression levels of PIAS1-PIAS4 genes in the circulation of patients with migraine compared with controls. Expression of PIAS1 was substantially lower in total migraineurs compared with controls (ratio of mean expressions (RME) = 0.18, SE = 0.29, P value < 0.001) and in both male and female migraineurs compared with sex-matched controls. Expression of PIAS2 was lower in migraineurs without aura compared with controls (RME = 0.64, SE = 0.31, P value = 0.04) and in male subgroup of these patients compared with male controls (RME = 0.60, SE = 0.22, P value < 0.001). In migraineurs with aura, downregulation of PIAS2 was only observed among male subgroups (RME = 0.37, SE = 0.49, P value = 0.01). PIAS3 was downregulated in total male migraineurs (RME = 0.52, SE = 0.43, P value = 0.04) and in male migraineurs with aura (RME = 0.49, SE = 0.45, P value = 0.03) compared with male controls. Finally, PIAS4 was upregulated in total migraineurs (RME = 3.78, SE = 0. 34, P value < 0.001), female migraineurs (RME = 5.26, SE = 0.36, P value < 0.001), migraineurs with aura (RME = 4.24, SE = 0.42, P value < 0.001), female migraineurs with aura (RME = 6.13, SE = 0.47, P value < 0.001), migraineurs without aura (RME = 3.33, SE = 0.38, P value < 0.001), and female migraineurs without aura (RME = 4.47, SE = 0.41, P value < 0.001) compared with the corresponding controls. The present study suggests contribution of PIAS genes in the pathogenesis of migraine and warrants future studies to clarify the functional routes of their contribution.
偏头痛是一种复杂的致残性疾病，与多种途径的失调有关，特别是与免疫反应有关的途径。为了评估蛋白抑制物激活 STAT（PIAS）在偏头痛发病机制中的作用，我们比较了偏头痛患者和对照组循环中 PIAS1-PIAS4 基因的表达水平。与对照组相比，总偏头痛患者的 PIAS1 表达明显降低（均数表达比（RME）=0.18，SE=0.29，P 值<0.001），男性和女性偏头痛患者也低于性别匹配的对照组。与对照组相比，无先兆偏头痛患者的 PIAS2 表达降低（RME=0.64，SE=0.31，P 值=0.04），且这些患者的男性亚组也低于男性对照组（RME=0.60，SE=0.22，P 值<0.001）。在有先兆偏头痛患者中，仅观察到男性亚组的 PIAS2 下调（RME=0.37，SE=0.49，P 值=0.01）。PIAS3 在总男性偏头痛患者（RME=0.52，SE=0.43，P 值=0.04）和男性有先兆偏头痛患者（RME=0.49，SE=0.45，P 值=0.03）中下调，与男性对照组相比。最后，PIAS4 在总偏头痛患者（RME=3.78，SE=0.34，P 值<0.001）、女性偏头痛患者（RME=5.26，SE=0.36，P 值<0.001）、有先兆偏头痛患者（RME=4.24，SE=0.42，P 值<0.001）、女性有先兆偏头痛患者（RME=6.13，SE=0.47，P 值<0.001）、无先兆偏头痛患者（RME=3.33，SE=0.38，P 值<0.001）和女性无先兆偏头痛患者（RME=4.47，SE=0.41，P 值<0.001）中上调，与相应的对照组相比。本研究提示 PIAS 基因在偏头痛发病机制中的作用，并需要进一步研究阐明其作用的功能途径。
