Hill G A, Diamond M P, Maxson W S, Herbert C M, Webster B W, Vaughn W K, Osteen K G, Rogers B J, Wentz A C
J In Vitro Fert Embryo Transf. 1987 Feb;4(1):34-9. doi: 10.1007/BF01555433.
Various protocols have been utilized for stimulation of multiple ovarian follicles in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Previous studies have suggested that the combination of clomiphene citrate (CC) and human menopausal gonadotropins (hMG) is superior to either CC or hMG alone in terms of follicular development, oocyte recovery, and embryo transfer. However, no significant increase in viable pregnancy rates has been reported with any of the protocols. This report examines five different CC/hMG protocols. While differences were seen in terms of serum estradiol response and fertilization rates of mature oocytes among the various protocols, no significant differences were found in terms of follicular development, oocyte recovery, embryo transfer, or pregnancy. The pregnancy rate in IVF-ET appears unaffected by variations in the dose and timing of CC and hMG in a combination protocol.
多种方案已被用于刺激接受体外受精-胚胎移植（IVF-ET）的患者的多个卵巢卵泡。先前的研究表明，枸橼酸氯米芬（CC）与人绝经期促性腺激素（hMG）联合使用在卵泡发育、卵母细胞回收和胚胎移植方面优于单独使用CC或hMG。然而，尚无任何方案报告活产妊娠率有显著提高。本报告研究了五种不同的CC/hMG方案。虽然不同方案之间在血清雌二醇反应和成熟卵母细胞受精率方面存在差异，但在卵泡发育、卵母细胞回收、胚胎移植或妊娠方面未发现显著差异。IVF-ET中的妊娠率似乎不受联合方案中CC和hMG剂量及给药时间变化的影响。
