正常人造血细胞中尿激酶和组织型纤溶酶原激活物与分化相关的分泌
Differentiation-linked secretion of urokinase and tissue plasminogen activator by normal human hemopoietic cells.
作者信息
Wilson E L, Francis G E
出版信息
J Exp Med. 1987 Jun 1;165(6):1609-23. doi: 10.1084/jem.165.6.1609.
Abstract
Previous studies have shown that the response of patients with acute myeloid leukemia to induction chemotherapy can be predicted by the species of plasminogen activator that their cells secrete. Patients whose cells secreted tissue plasminogen activator (tPA) only failed to respond to combination chemotherapy. Individuals whose leukemic cells display features of the early progenitor phenotype also respond poorly to therapy. This suggested that the two species of plasminogen activator secreted by leukemic cells might be produced by normal cells at distinct stages of differentiation. These results indicate that the secretion of the two enzyme types is a differentiation-linked property of normal cells with tPA being produced by granulocyte/macrophage progenitors and urokinase by more differentiated cells and by mature neutrophils and macrophages.
摘要
先前的研究表明，急性髓系白血病患者对诱导化疗的反应可通过其细胞分泌的纤溶酶原激活物种类来预测。细胞仅分泌组织型纤溶酶原激活物（tPA）的患者对联合化疗无反应。白血病细胞表现出早期祖细胞表型特征的个体对治疗的反应也较差。这表明白血病细胞分泌的两种纤溶酶原激活物可能由正常细胞在不同分化阶段产生。这些结果表明，这两种酶的分泌是正常细胞的一种与分化相关的特性，其中tPA由粒细胞/巨噬细胞祖细胞产生，而尿激酶由分化程度更高的细胞以及成熟的中性粒细胞和巨噬细胞产生。
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