Raynor William Y, Zadeh Mahdi Zirakchian, Kothekar Esha, Yellanki Dani P, Alavi Abass
Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Drexel University College of Medicine, 2900 W Queen Lane, Philadelphia, PA 19129, USA.
Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
PET Clin. 2019 Jul;14(3):331-340. doi: 10.1016/j.cpet.2019.03.003. Epub 2019 Apr 10.
"The role of F-fluorodeoxyglucose PET/computed tomography in hematological malignancies continues to expand in disease diagnosis, staging, and management. A key advantage of PET over other imaging modalities is its ability to quantify tracer uptake, which can be used to determine degree of disease activity. Although tracer uptake with PET is conventionally measured in focal lesions, novel quantitative techniques are being investigated that set objective protocols and produce robust parameters that represent total disease activity portrayed by PET. This article discusses recent advances in PET quantification that can improve reliability and accuracy of characterizing hematological malignancies."
18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）在血液系统恶性肿瘤的疾病诊断、分期及管理中的作用不断扩大。PET相对于其他成像方式的一个关键优势在于其能够对示踪剂摄取进行量化，这可用于确定疾病活动程度。虽然传统上PET的示踪剂摄取是在局灶性病变中测量的，但正在研究新的定量技术，这些技术设定了客观方案并产生代表PET所描绘的总疾病活动的可靠参数。本文讨论了PET定量方面的最新进展，这些进展可提高血液系统恶性肿瘤特征描述的可靠性和准确性。
