Laboratorio MANLAB, Área de Filiaciones, Buenos Aires, Argentina.
Laboratorio de Diversidad Genética, Instituto Multidisciplinario de Biología Celular IMBICE, La Plata, Buenos Aires, Argentina; Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
Forensic Sci Int Genet. 2019 Jul;41:e8-e13. doi: 10.1016/j.fsigen.2019.04.005. Epub 2019 May 10.
The analysis of X-chromosome STRs is useful in certain kinship cases for which autosomal markers provide insufficient statistical power. Particularly, powerful results are achieved in paternity cases with a daughter, when the alleged father is not accessible for analysis, contrarily to his unquestioned mother or daughter. However, representative haplotype frequencies for this type of markers are not available for some populations, as is the case of Argentina, which prevents the quantification of the proof in routine forensic analyses. In this work we present haplotype frequencies for the 12 X-chromosome STRs included in the Investigator Argus X-12 kit, as well as segregation data, obtained from the analysis of the genetic profiles of 457 father-daughter duos, which gave us information on 914 (unrelated) haplotypes from residents of all Argentinian provinces.
X 染色体 STR 分析在某些亲缘关系案例中很有用，对于这些案例，常染色体标记物提供的统计效力不足。特别是在涉及女儿的亲子鉴定案例中，如果被怀疑的父亲无法进行分析（与他无疑是母亲或女儿的情况相反），则可以获得有力的结果。然而，某些人群（如阿根廷）没有此类标记物的代表性单倍型频率，这使得在常规法医分析中无法对证据进行量化。在这项工作中，我们展示了 Investigator Argus X-12 试剂盒中包含的 12 个 X 染色体 STR 的单倍型频率，以及从对来自阿根廷所有省份的 457 对父女的遗传谱分析中获得的分离数据，这些数据为我们提供了来自 914 个（无关）单倍型的信息。
