Holtz L, Milton J, Sturek J K
JPEN J Parenter Enteral Nutr. 1987 Mar-Apr;11(2):183-6. doi: 10.1177/0148607187011002183.
Administration of medications to patients with nasogastric tubes has traditionally been done in a bolus fashion. An alternative to this would be to mix the medications in the continuous drip enteral feeding with subsequent continuous administration. The purpose of this study was to determine the compatibility of select medications with Ensure, Ensure Plus, and Osmolite. We observed neither visible abnormalities in the mixtures nor change in pH of the enteral products after the addition of digoxin, theophylline, phenytoin, methyldopa, or furosemide. The addition of theophylline to all three enteral products caused a substantial increase in the osmolality. We also examined the concentrations of the mixtures to detect any changes occurring over the 12-hr infusion time. A wide variation in concentrations after the addition of phenytoin suspension was corrected by adding the injectable form to the enteral products. Digoxin and furosemide concentrations were essentially unchanged; however, the methyldopa concentration decreased up to 23% over the 12-hr study period. We, therefore, cannot recommend the addition of theophylline, phenytoin suspension, or methyldopa to the three enteral products tested.
传统上，给通过鼻胃管进食的患者用药采用大剂量推注的方式。另一种方法是将药物混入持续滴注的肠内营养液中随后持续给药。本研究的目的是确定某些药物与安素、安素益力佳和能全力的相容性。在加入地高辛、茶碱、苯妥英、甲基多巴或呋塞米后，我们观察到混合液中未见明显异常，肠内产品的pH值也未改变。向所有三种肠内产品中加入茶碱导致渗透压大幅升高。我们还检测了混合液的浓度，以发现12小时输注时间内发生的任何变化。加入苯妥英混悬液后浓度变化很大，通过向肠内产品中加入注射用苯妥英进行了校正。地高辛和呋塞米的浓度基本未变；然而，在12小时的研究期间，甲基多巴的浓度下降了高达23%。因此，我们不建议在测试的三种肠内产品中加入茶碱、苯妥英混悬液或甲基多巴。
