Cutie A J, Altman E, Lenkel L
JPEN J Parenter Enteral Nutr. 1983 Mar-Apr;7(2):186-91. doi: 10.1177/0148607183007002186.
Although drugs are routinely administered through gavage feedings set along with enteral products, there is little scientific data available to the physician, pharmacist, nurse, and dietician concerning the physical and chemical compatibility of drugs with enteral formulations. This study assesses the compatibility of Ensure (Ross Laboratories, Columbus, OH), Ensure Plus (Ross Laboratories, Columbus, OH), Osmolite (Ross Laboratories, Columbus, OH) with antibiotics, gastrointestinal agents, antipsychotic agents, urinary antiseptics cough and cold medications, and other commonly used additives. All enteral formulations were examined immediately after mixing for phase changes, creaming, and particle growth using a contrast light and a rotation viscometer. Results are presented in a tabular format. Guidelines and recommendations concerning how the addition of troublesome drug additives can be added are also presented.
尽管药物通常与肠内产品一起通过灌胃给药，但医生、药剂师、护士和营养师几乎没有关于药物与肠内制剂物理和化学相容性的科学数据。本研究评估了安素（罗斯实验室，俄亥俄州哥伦布市）、加营素（罗斯实验室，俄亥俄州哥伦布市）、能全力（罗斯实验室，俄亥俄州哥伦布市）与抗生素、胃肠道药物、抗精神病药物、尿路消毒剂、止咳感冒药和其他常用添加剂的相容性。混合后立即使用比色计和旋转粘度计检查所有肠内制剂的相变、乳化和颗粒生长情况。结果以表格形式呈现。还给出了关于如何添加有问题的药物添加剂的指南和建议。
