免疫缺陷突变型hr/hr小鼠中T细胞亚群的比例失调。
Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice.
作者信息
Reske-Kunz A B, Scheid M P, Boyse E A
出版信息
J Exp Med. 1979 Jan 1;149(1):228-33. doi: 10.1084/jem.149.1.228.
Abstract
Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice.
摘要
对携带突变基因hr的HRS品系小鼠的脾脏中三种T细胞集落Ly1、Ly23和Ly123的表现异常进行了检测。与+/hr分离株相比，免疫缺陷的hr/hr小鼠的显著特征是，在3至3.5月龄时，属于Ly1和Ly123集落的细胞数量严重失衡。在这个年龄，hr/hr脾脏的Ly123细胞数量比Ly1细胞多两倍，而在+/hr脾脏中，Ly123细胞数量比约为1:2。来自hr/hr小鼠汇集淋巴结的细胞未显示出Ly1和Ly123细胞相应的严重失衡。hr/hr和+/hr小鼠的脾脏T细胞和B细胞总数没有显著差异。
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