T细胞集之间的免疫调节回路。诱导反馈抑制的辅助性T细胞亚群的鉴定。
Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.
作者信息
Cantor H, Hugenberger J, McVay-Boudreau L, Eardley D D, Kemp J, Shen F W, Gershon R K
出版信息
J Exp Med. 1978 Oct 1;148(4):871-7. doi: 10.1084/jem.148.4.871.
Abstract
Purified Ly1 cells induce other T-cell sets to exert potent feedback inhibitory activity and this T-T interaction has been shown to play an important role in regulating in vivo immune responses. Approximately 2/3 of Ly1 cells also express the Qa1 surface phenotype (Ly1:Qa1+ cells). The experiments reported here indicate that Ly1:Qal+ cells are responsible for induction of feedback inhibition and that signals from both Ly1:Qal+ cells and Ly1:Qal- cells are required for optimal formation of antibody by B cells.
摘要
纯化的Ly1细胞可诱导其他T细胞亚群发挥强大的反馈抑制活性，并且这种T细胞与T细胞间的相互作用已被证明在调节体内免疫反应中发挥重要作用。大约2/3的Ly1细胞也表达Qa1表面表型（Ly1:Qa1+细胞）。本文报道的实验表明，Ly1:Qa1+细胞负责诱导反馈抑制，并且来自Ly1:Qa1+细胞和Ly1:Qa1-细胞的信号都是B细胞最佳抗体形成所必需的。
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T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.T细胞对抗体应答的调节：同种异型特异性辅助性T细胞的证明及其被抑制性T细胞的特异性清除。
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Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.表达不同Ly成分的辅助性T细胞与抑制性T细胞的分离。II. 抗原激活：免疫后，抗原特异性抑制和辅助活性由不同的T细胞亚类介导。
J Exp Med. 1976 Jun 1;143(6):1391-40. doi: 10.1084/jem.143.6.1391.
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Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.体内抗半抗原抗体反应中的细胞协作。I. 细胞数量对反应的影响。
J Immunol. 1975 Apr;114(4):1394-401.
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Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.参与二次抗体应答的两种不同类型的辅助性T细胞：Ia⁺和Ia⁻辅助性T细胞的独立和协同效应
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