Parker Kyle E, Bruchas Michael R
Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA.
Department of Anesthesiology and Pain Medicine, Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Handb Exp Pharmacol. 2019;254:131-139. doi: 10.1007/164_2019_215.
The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a G protein-coupled receptor with wide distribution throughout the peripheral and central nervous system. Similar to other opioid receptors, NOP receptors couple to intracellular second messengers and regulatory proteins to affect biological systems. In this chapter, we review the current literature for NOP signaling cascades including their role as classic GPCRs, the investigation of their kinase and arrestin signaling pathways, and the importance of examining biased signaling to critically evaluate the therapeutic potential of novel NOP agonists.
痛敏肽/孤啡肽FQ（N/OFQ）肽（NOP）受体是一种G蛋白偶联受体，广泛分布于外周和中枢神经系统。与其他阿片受体类似，NOP受体与细胞内第二信使和调节蛋白偶联，以影响生物系统。在本章中，我们综述了关于NOP信号级联反应的当前文献，包括它们作为经典GPCR的作用、对其激酶和阻遏蛋白信号通路的研究，以及研究偏向性信号传导对于严格评估新型NOP激动剂治疗潜力的重要性。
