Nabeshima T, Ishikawa K, Yamaguchi K, Furukawa H, Kameyama T
Neurosci Lett. 1987 May 19;76(3):335-8. doi: 10.1016/0304-3940(87)90425-3.
This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg, i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.
本研究旨在评估选择性5-羟色胺（5-HT2）受体拮抗剂利坦色林是否能拮抗苯环利定（PCP）诱导的小鼠和大鼠头部抽搐，以确认5-羟色胺（5-HT）神经元在PCP作用中的参与情况，并与5-甲氧基-N，N-二甲基色胺（5-MeODMT）诱导的行为进行比较。PCP（7.5、10和12.5mg/kg，腹腔注射）诱导的小鼠和大鼠头部抽搐被利坦色林（1mg/kg，皮下注射）完全拮抗，5-MeODMT（2和4mg/kg，腹腔注射）诱导的小鼠头部抽搐也被利坦色林完全拮抗。利坦色林处理后，PCP和5-MeODMT在小鼠中诱导头部摆动，但在大鼠中未出现这种情况。在大鼠中，5-MeODMT未能诱导头部抽搐。这些结果表明，PCP诱导的大鼠头部抽搐反应是通过5-HT2受体产生的，它是一个有用的5-HT2受体模型，而5-MeODMT诱导的大鼠头部摆动是通过5-HT1受体产生的，是一个有用的5-HT1受体模型。
