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Industrialization of Quantitative Systems Pharmacology.

作者信息

Topp Brian, Trujillo Maria E, Sinha Vikram

机构信息

Quantitative Pharmacology and Pharmacometrics, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey, USA.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):356-358. doi: 10.1002/psp4.12427. Epub 2019 Jun 6.

DOI:10.1002/psp4.12427
PMID:31087476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6617811/
Abstract
摘要

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The future of drug development: the paradigm shift towards systems therapeutics.
药物研发的未来：向系统治疗学的范式转变。
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Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.酸鞘磷脂酶缺乏症的定量系统药理学模型和酶替代疗法奥利普达斯α是连接病理生理学和药理学的创新工具。
CPT Pharmacometrics Syst Pharmacol. 2018 Jul;7(7):442-452. doi: 10.1002/psp4.12304. Epub 2018 Jun 19.
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A model qualification method for mechanistic physiological QSP models to support model-informed drug development.一种用于支持模型指导药物开发的机制性生理QSP模型的模型验证方法。
CPT Pharmacometrics Syst Pharmacol. 2016 Feb;5(2):43-53. doi: 10.1002/psp4.12056. Epub 2016 Jan 26.
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The future is now: model-based clinical trial design for Alzheimer's disease.未来已来：阿尔茨海默病基于模型的临床试验设计
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NIH Support for the Emergence of Quantitative and Systems Pharmacology.美国国立卫生研究院对定量与系统药理学兴起的支持。
CPT Pharmacometrics Syst Pharmacol. 2013 Apr 10;2(4):e37. doi: 10.1038/psp.2013.13.
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A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling.一个钙稳态和骨重建综合的生理基础数学模型。
Bone. 2010 Jan;46(1):49-63. doi: 10.1016/j.bone.2009.08.053. Epub 2009 Sep 2.