Yukitake Motohiro
Neurology, Kouhoukai Takagi Hospital.
Brain Nerve. 2019 May;71(5):493-505. doi: 10.11477/mf.1416201301.
Here, progressive multifocal leukoencephalopathy (PML) and PML in systemic lupus erythematosus (SLE) are reviewed. Disease-modifying therapy (DMT) associated PML is an emerging condition, particularly in multiple sclerosis patients. Although PML is a rare adverse event in SLE, we should consider development of PML more carefully in not only conventional drug-induced PML but also DMT associated PML during SLE treatment in the era of DMT associated PML.
在此，对进行性多灶性白质脑病（PML）及系统性红斑狼疮（SLE）中的PML进行综述。疾病修饰疗法（DMT）相关的PML是一种新出现的情况，尤其在多发性硬化症患者中。尽管PML在SLE中是一种罕见的不良事件，但在DMT相关PML的时代，我们在SLE治疗期间不仅应更谨慎地考虑传统药物诱发的PML，还应考虑DMT相关的PML的发生。
