Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Department of Radiation Biology and Radiotherapy, University of Lagos, Lagos, Nigeria.
Q J Nucl Med Mol Imaging. 2022 Mar;66(1):52-60. doi: 10.23736/S1824-4785.19.03156-X. Epub 2019 May 8.
To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-FDG-PET/CT.
We reviewed the F-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment, histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-FDG-PET/CT study.
We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99±9.30 years) compared to HIV-uninfected (50.19±11.09), P<0.001. Local recurrence was present in 125 patients while 100 patients had a distant recurrence. Recurrence occurred at a single site in 88 patients and two or more sites in 110 patients. No significant difference in the recurrent patterns between HIV-infected and uninfected patients. Median time to recurrence was 10.50 months (range: 6.00-156.00) among HIV-infected versus 12.00 months (IQR:7.00-312.00) among the uninfected, P=0.065. FIGO stage III (P=0.042) and the presence of histological sub-types other than SCC (P=0.005) were significant predictors of recurrence. HIV infection by itself was not significant in predicting recurrence (P=0.843).
HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.
比较 HIV 感染者和非感染者宫颈癌的复发率、时间和模式，并确定评估 F-FDG-PET/CT 后预测宫颈癌复发的因素。
我们回顾了经组织学证实患有宫颈癌且有疑似复发的患者的 F-FDG-PET/CT 图像。我们从电子实验室数据库和 F-FDG-PET/CT 研究转诊表中提取了流行病学数据、既往治疗、组织学亚型、HIV 状态、病毒载量和 CD4 计数。
我们研究了 303 名女性，其中包括 112 名 HIV 感染者。131 名患者为 FIGO 分期 III 期疾病。在 198 名有复发的患者中，74 名 HIV 感染者，124 名非 HIV 感染者（P=0.849）。与非 HIV 感染者相比，HIV 感染者更年轻（41.99±9.30 岁），P<0.001。125 名患者出现局部复发，100 名患者出现远处转移。88 名患者仅出现一处复发，110 名患者出现两处或更多处复发。在 HIV 感染者和非感染者之间，复发模式无显著差异。HIV 感染者的中位复发时间为 10.50 个月（范围：6.00-156.00），非感染者为 12.00 个月（IQR：7.00-312.00），P=0.065。FIGO 分期 III 期（P=0.042）和组织学亚型非 SCC（P=0.005）是复发的显著预测因素。HIV 感染本身对预测复发无显著影响（P=0.843）。
在疑似宫颈癌复发的女性中，HIV 感染对复发率、时间或模式无显著影响。晚期疾病和非 SCC 组织学亚型是复发的预测因素。
