Boffa Giacomo, Lapucci Caterina, Morbelli Silvia D, Nobili Flavio M
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy -
San Martino Hospital and Institute for Cancer Research and Care, Genoa, Italy -
Q J Nucl Med Mol Imaging. 2019 Jun;63(2):225-226. doi: 10.23736/S1824-4785.19.03171-6. Epub 2019 May 8.
The term diaschisis refers to a neural dysfunction manifesting in anatomically intact, but functionally related, brain regions distant from a primary lesion. Here we report the diaschisis phenomenon as a consequence of a first demyelinating event in the middle and superior cerebellar peduncles in both the ipsilateral cerebellar hemisphere and in the contralateral thalamus and cerebral cortex (two-way crossed cerebellar diaschisis), resulting in the simultaneous disruption of the afferent cortico-ponto-cerebellar pathway and the efferent cerebellar-thalamo-cortical pathway. The use of 18F-FDG-PET could help clarifying in vivo the distant pathophysiological effect of focal lesions in inflammatory diseases such as multiple sclerosis.
“远隔性机能障碍”一词是指在解剖结构完整但功能相关的、远离原发性病变的脑区出现的神经功能障碍。在此我们报告，作为中脑和上小脑脚首次脱髓鞘事件的结果，在同侧小脑半球以及对侧丘脑和大脑皮质出现远隔性机能障碍现象（双向交叉性小脑远隔性机能障碍），导致传入性皮质-脑桥-小脑通路和传出性小脑-丘脑-皮质通路同时中断。使用18F-FDG-PET有助于在活体中阐明诸如多发性硬化症等炎症性疾病中局灶性病变的远距离病理生理效应。
