Spoorendonk Jelle A, Krol Marieke, Alleman Cathelijne
Pharmerit International, Rotterdam, the Netherlands -
IQVIA, Amsterdam, the Netherlands.
J Cardiovasc Surg (Torino). 2020 Aug;61(4):435-444. doi: 10.23736/S0021-9509.19.10936-6. Epub 2019 May 10.
Peripheral arterial disease (PAD) can lead to severe cases of critical limb ischemia (CLI), which in turn might lead to amputation. Amputation can have substantial consequences for patients. This publication aims to give a better understanding of the amputation-related burden in patients with PAD in the Netherlands.
A systematic review and grey literature searches were conducted followed by qualitative interviews with a multidisciplinary team of clinical experts in amputation. Subsequently, IQVIA's Dutch hospital claims data were analyzed.
Twenty-seven publications were identified. Dutch claims data identified claims for 2328 patients after amputation for PAD. Data for the following topics were found: incidence, mortality, complications, mobility, daily functioning, quality of life, utilities, length of stay (LoS), costs, and resource use. Annually, 90% of the 3300 amputations carried out in the Netherlands were due to vascular disease. One-year mortality in patients with an amputation ranged from 49.6% (above-the-knee amputation) to 9% (specialized care). Patients' quality of life was substantially affected and utility of post-major amputation for PAD was 0.54. LoS after amputation varied from 11.4 (general rehabilitation) to 53.4 days (amputation of the leg). Total budget incurred based on frequently claimed DBC's from Dutch claims data in patients with PAD undergoing an amputation over 2012 to 2016 was € 136,651,374. Mean cost per patient was € 17,821.
Amputation leads to substantial burden in patients with PAD in the Netherlands. Identified results give a better understanding of the specific Dutch burden of amputation.
外周动脉疾病（PAD）可导致严重的肢体严重缺血（CLI），进而可能导致截肢。截肢会给患者带来重大影响。本出版物旨在更深入了解荷兰PAD患者的截肢相关负担。
进行了系统综述和灰色文献检索，随后对截肢方面的多学科临床专家团队进行了定性访谈。随后，对IQVIA的荷兰医院理赔数据进行了分析。
共识别出27篇出版物。荷兰理赔数据确定了2328例因PAD截肢患者的理赔情况。发现了以下主题的数据：发病率、死亡率、并发症、 mobility、日常功能、生活质量、效用、住院时间（LoS）、成本和资源使用。在荷兰，每年进行的3300例截肢手术中有90%是由血管疾病导致的。截肢患者的一年死亡率在49.6%（膝上截肢）至9%（专科护理）之间。患者的生活质量受到严重影响，PAD大截肢后的效用为0.54。截肢后的住院时间从11.4天（一般康复）到53.4天（腿部截肢）不等。根据2012年至2016年荷兰理赔数据中PAD截肢患者经常申报的诊断相关组（DBC）计算的总预算为136,651,374欧元。每位患者的平均成本为17,821欧元。
截肢给荷兰的PAD患者带来了重大负担。已确定的结果能更好地了解荷兰截肢的具体负担。
原文中“mobility”未翻译，可能是有拼写错误或不完整信息，正常情况下应结合上下文准确翻译其含义。
