[特发性正常压力脑积水患者脑活检的病理变化]
[Pathological changes in human brain biopsies from patients with idiopathic normal pressure hydrocephalus].
作者信息
Gavrilov G V, Stanishevskiy A V, Gaydar B V, Paramonova N M, Gaykova O N, Svistov D V
机构信息
Kirov Military Medical Academy, St.-Petersburg, Russia.
Kirov Military Medical Academy, St.-Petersburg, Russia; Sechenov Institute of Evolutionary Physiology and Biochemistry, St.-Petersburg, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(3):50-54. doi: 10.17116/jnevro201911903150.
AIM
To analyze specific changes in brain tissue of patients with idiopathic normal pressure hydrocephalus at cellular and subcellular levels.
MATERIAL AND METHODS
Brain biopsies from 32 patients with idiopathic normal pressure hydrocephalus were investigated by light and electron microscopy. Biopsies were made in 3 points (the cortex, subcortical and periventricular white matter during ventricular catheter positioning).
RESULTS
A number of pathological features of idiopathic normal pressure hydrocephalus were identified. Most frequent were the exhaustion of brain tissue, enlargement of perivascular spaces, aseptic necrosis, and amyloid and Lewy body's formation.
CONCLUSION
The changes in brain tissue of patients with idiopathic normal pressure hydrocephalus transform our views on its mechanisms. It becomes clear that idiopathic normal pressure hydrocephalus is part of common neurodegenerative process that has characteristic features affecting clinical manifestations of the disease.
目的
在细胞和亚细胞水平分析特发性正常压力脑积水患者脑组织的具体变化。
材料与方法
对32例特发性正常压力脑积水患者的脑活检组织进行光镜和电镜检查。在脑室导管定位时于3个部位（皮质、皮质下和脑室周围白质）取材。
结果
确定了特发性正常压力脑积水的一些病理特征。最常见的是脑组织耗竭、血管周围间隙扩大、无菌性坏死以及淀粉样蛋白和路易小体形成。
结论
特发性正常压力脑积水患者脑组织的变化改变了我们对其发病机制的看法。很明显，特发性正常压力脑积水是常见神经退行性过程的一部分，该过程具有影响疾病临床表现的特征。
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