Marchesi C, Gnudi A, Chiodera P, De Risio C, Fava A, Dasso L, De Ferri A, Guerra M, Coiro V
Pharmacopsychiatry. 1987 Mar;20(2):64-6. doi: 10.1055/s-2007-1017077.
In an attempt to establish whether, in patients with major depression, dopaminergic receptors are involved in the release of growth hormone (GH) induced by thyrotropin releasing hormone (TRH), eleven subjects were tested with TRH (200 micrograms in an i.v. bolus) with or without concomitant treatment with domperidone (10 mg in an i.v. bolus 10 min before TRH), an antidopaminergic agent which does not readily cross the blood-brain barrier. In 7 out of the 11 patients, TRH strikingly increased GH levels (responders) (the mean peak level was 9 times higher than basal value), whereas it was without effect in the remaining 4 patients (non-responders). When the responders were treated with domperidone before TRH injection, TRH-induced GH increase was still present, but it was significantly lower (the mean peak level was 5.3 times higher than basal value) than in the TRH test (p less than 0.02). These data suggest that the paradoxical response of GH or TRH in patients with major depression involves a dopaminergic mechanism active at sites situated outside the blood-brain barrier.
为了确定在重度抑郁症患者中，多巴胺能受体是否参与促甲状腺激素释放激素（TRH）诱导的生长激素（GH）释放，对11名受试者进行了TRH（静脉推注200微克）测试，测试时伴有或不伴有多潘立酮（在TRH前10分钟静脉推注10毫克）治疗，多潘立酮是一种不易穿过血脑屏障的抗多巴胺能药物。11名患者中有7名，TRH显著提高了GH水平（反应者）（平均峰值水平比基础值高9倍），而其余4名患者（无反应者）则无此效果。当反应者在注射TRH前接受多潘立酮治疗时，TRH诱导的GH升高仍然存在，但明显低于TRH测试时的升高水平（平均峰值水平比基础值高5.3倍）（p<0.02）。这些数据表明，重度抑郁症患者中GH对TRH的反常反应涉及一种在血脑屏障外部位起作用的多巴胺能机制。
