Meyer F P, Walther H
Psychiatr Neurol Med Psychol (Leipz). 1987 Jan;39(1):1-16.
Antiepileptics can impair the performance of subjects in both acute and subacute doses. The effects of phenobarbital and its derivatives and benzodiazepines are stronger in this respect than that of phenytoin, ethosuccimides and valproic acid. Carbamazepine, in contrast, has rather a stimulatory action. Impaired cognition, psychomotor performance and emotions must also be expected under therapeutic conditions. Attention is drawn to various factors that may influence the results of tests, including the dose and blood concentration, interval between application and test, initial performance of the probands or patients, levels of vigilance and personality structure. Lack of compliance is particularly important since adaptation and readaptation processes that can be dangerous take place in these patients. The careful exploration of side-effects on the patient may have a decisive influence on practicability and cost if the relationship between patient and doctor is good.
抗癫痫药物在急性和亚急性剂量下均会损害受试者的表现。在这方面，苯巴比妥及其衍生物和苯二氮䓬类药物的作用比苯妥英钠、乙琥胺和丙戊酸更强。相比之下，卡马西平具有相当的刺激作用。在治疗条件下，认知、精神运动表现和情绪受损也在预期之中。请注意各种可能影响测试结果的因素，包括剂量和血药浓度、用药与测试之间的间隔、受试者或患者的初始表现、警觉水平和人格结构。缺乏依从性尤为重要，因为这些患者会发生可能危险的适应和再适应过程。如果医患关系良好，对患者副作用的仔细探究可能对实用性和成本产生决定性影响。
