Faculty of Dentistry, Oral & Craniofacial Sciences, King's College, London, UK.
Periodontol 2000. 2019 Jun;80(1):61-76. doi: 10.1111/prd.12264.
Inflammatory bowel disease has a wide range of possible oral manifestations, many of which overlap with those seen in other conditions, including orofacial granulomatosis. The precise etiology remains unclear, as is the exact relationship between orofacial granulomatosis and Crohn's disease. Overall, there is growing evidence that orofacial granulomatosis and oral Crohn's disease are distinct clinical disorders with optimal management requiring a multidisciplinary approach with input from appropriate specialists in oral medicine, gastroenterology, allergy, dietetics, and clinical psychology. This review details the etiopathogenesis, clinical presentation, epidemiology, extra-intestinal, and oral manifestations of inflammatory bowel disease and orofacial granulomatosis. It also assesses the current role of investigations in the diagnosis of orofacial granulomatosis and critically reviews the available evidence in relation to medical and surgical interventions for the condition, and its relationship to Crohn's disease.
炎症性肠病有广泛的可能的口腔表现，其中许多与其他疾病中观察到的重叠，包括口腔肉芽肿病。确切的病因仍不清楚，口腔肉芽肿病和克罗恩病之间的确切关系也是如此。总的来说，越来越多的证据表明，口腔肉芽肿病和口腔克罗恩病是两种不同的临床疾病，最佳的管理需要多学科的方法，需要口腔医学、胃肠病学、过敏、营养学和临床心理学等相关专业人员的参与。这篇综述详细描述了炎症性肠病和口腔肉芽肿病的发病机制、临床表现、流行病学、肠外和口腔表现。它还评估了目前在口腔肉芽肿病诊断中的检查作用，并批判性地回顾了关于该疾病的医学和手术干预以及与克罗恩病的关系的现有证据。
