达格列净治疗对 2 型糖尿病患者心室复极异质性的纵向影响。
Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes.
机构信息
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan.
出版信息
J Diabetes Investig. 2019 Nov;10(6):1593-1594. doi: 10.1111/jdi.13063. Epub 2019 May 15.
QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak-Tend/QT in a subgroup with Tpeak-Tend/QT?0.25 (median).
达格列净治疗 24 周时 QTc 离散度（QTcd）趋于降低，治疗 2 年后显著降低。在 QTcd?53.7ms（中位数）的亚组中，24 周时 QTcd 显著降低，且改善持续 2 年。在 Tpeak-Tend/QT?0.25（中位数）的亚组中，达格列净还显著降低 Tpeak-Tend/QT。
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