肿瘤免疫学和免疫疗法：我从杭州开始的一段旅程。
Tumor immunology and immunotherapy: a journey I started from Hangzhou.
机构信息
Department of Pathology, School of Medicine; Molecular Biology Section, Division of Biological Sciences; Moores Cancer Center, University of California at San Diego, La Jolla, California 92093-0864, USA.
出版信息
J Zhejiang Univ Sci B. 2019 May;20(5):373-380. doi: 10.1631/jzus.B1900204.
Abstract
This short article is dedicated to the 90th Anniversary of the School of Life Sciences at Zhejiang University, China. Immunotherapy of cancer is currently a hot topic in the biomedical field, and a re-search focus of my laboratory is on developing new and effective combinatorial immunotherapeutic strategies for liver cancer. Of note, my interest in immunotherapy of cancer stems from the training as an undergraduate student at Hangzhou University, China, almost 40 years ago.
摘要
本文谨献给中国浙江大学生命科学学院 90 周年校庆。癌症的免疫疗法目前是生物医学领域的热门话题，我的实验室的研究重点之一是开发针对肝癌的新型有效的组合免疫治疗策略。值得注意的是，我对癌症免疫疗法的兴趣源于近 40 年前在中国杭州大学的本科学习。
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本文引用的文献
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An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice.一种通过协调激活固有和适应性免疫的原发性肝癌高效联合免疫疗法。
Hepatology. 2019 Jun;69(6):2518-2532. doi: 10.1002/hep.30528. Epub 2019 Mar 13.
2
Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.系统性激活固有免疫功能预防肝癌发生。
Cell Rep. 2017 Nov 14;21(7):1870-1882. doi: 10.1016/j.celrep.2017.10.064.
3
Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.Shp2和Pten在骨髓增殖中具有拮抗作用，但在哺乳动物中协同促进红细胞生成。
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13342-7. doi: 10.1073/pnas.1507599112. Epub 2015 Oct 12.
4
Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox.分子在肝癌发生中的相互矛盾作用：范例还是悖论。
Cancer Cell. 2012 Feb 14;21(2):150-4. doi: 10.1016/j.ccr.2012.01.001.
5
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.Ptpn11/SHP2 在肝细胞癌发生中作为一种肿瘤抑制因子发挥作用。
Cancer Cell. 2011 May 17;19(5):629-39. doi: 10.1016/j.ccr.2011.03.023.
6
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.PTPN11是首个被鉴定出的编码酪氨酸磷酸酶的原癌基因。
Blood. 2007 Feb 1;109(3):862-7. doi: 10.1182/blood-2006-07-028829. Epub 2006 Oct 19.
7
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.Gab1与Shp2在肝脏再生和肝脏保护中的协同作用。
Mol Cell Biol. 2006 Jun;26(12):4664-74. doi: 10.1128/MCB.02253-05.
8
Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.Shp-2 酪氨酸磷酸酶在淋巴细胞和造血细胞发育中的需求。
Blood. 2001 Feb 15;97(4):911-4. doi: 10.1182/blood.v97.4.911.
9
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.含有Shp-2突变细胞的嵌合小鼠中造血作用的偏向性抑制和多种发育缺陷。
Mol Cell Biol. 1998 Oct;18(10):6075-82. doi: 10.1128/MCB.18.10.6075.
10
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.Shp-2的SH2-N结构域中的缺失突变严重抑制造血细胞发育。
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