Burnevich E S, Popova E N, Ponomarev A B, Nekrasova T P, Lebedeva M V, Filatova A L, Shchanitcyna E M, Ponomareva L A, Beketov V D, Bondarenko I B, Tanashchuk E L, Nikulkina E N, Moiseev S V
Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
City Clinical Hospital №24 of the Department of Health of Moscow, Moscow, Russia.
Ter Arkh. 2019 Mar 11;91(1):89-94. doi: 10.26442/00403660.2019.01.000036.
Clinical features of overlap autoimmune hepatitis/primary biliary cholangitis and morphological-proved sarcoid lesions (lungs, lymph nodes, skin) were performed. Data of long-term clinical observation presented in comparison with the results of laboratory datas, instrumental and morphological studies of liver tissue, lungs, skin. The modern aspects of pathogenesis of association autoimmune and granulomatous diseases arediscussed on the example of clinical cases of combination of cholestatic variants of autoimmune hepatitis and generalized sarcoidosis. Keywords: sarcoidosis, autoimmune hepatitis, primary biliary cholangitis, primary biliary cholangitis-autoimmune hepatitis-overlap, extrahepatic manifestations.
对重叠性自身免疫性肝炎/原发性胆汁性胆管炎的临床特征以及经形态学证实的结节病病变（肺、淋巴结、皮肤）进行了研究。将长期临床观察数据与肝脏组织、肺、皮肤的实验室数据、仪器检查和形态学研究结果进行了比较。以自身免疫性肝炎胆汁淤积型变体与全身性结节病合并的临床病例为例，讨论了自身免疫性和肉芽肿性疾病关联发病机制的现代观点。关键词：结节病、自身免疫性肝炎、原发性胆汁性胆管炎、原发性胆汁性胆管炎-自身免疫性肝炎重叠、肝外表现
