The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials , Shanghai Normal University , Shanghai 200234 , P.R. China.
J Org Chem. 2019 Jun 7;84(11):6557-6564. doi: 10.1021/acs.joc.9b00999. Epub 2019 May 22.
The efficient and practical nucleophilic cyanation and trifluoromethylation with appropriate trimethylsilyl nucleophiles were developed. Catalytic amounts of cheap and nontoxic CsCO were used to maintain a sufficiently high concentration of nucleophilic anion (CN or CF) which could begin the catalytic cycle. The present methodologies provide diverse functionalized monofluoroalkenes bearing a cyano and trifluoromethyl group with excellent to moderate stereoselectivities.
发展了高效实用的亲核氰化和三氟甲基化反应，使用合适的三甲基硅亲核试剂。催化量的廉价无毒 CsCO 用于维持足够高的亲核阴离子（CN 或 CF）浓度，从而引发催化循环。本方法学提供了多种具有氰基和三氟甲基官能团的官能化单氟烯烃，立体选择性优异至中等。
