消防人员引发的急性炎症反应不能被阿司匹林缓解。
Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters.
机构信息
Department of Health and Human Physiological Sciences, Skidmore College, Saratoga Springs, New York (Drs Smith, Friedman, Bloom, Armero), School of Health Studies, University of Memphis, Memphis, Tennessee (Dr Pence), Department of Human Performance & Leisure Studies, North Carolina A&T State University, Greensboro, North Carolina (Dr Cook), Department of Kinesiology & Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, Illinois (Dr Fernhall), Department of Mechanical Science and Engineering, University of Illinois, Urbana-Champaign, Illinois (Dr Horn), Illinois Fire Service Institute, Urbana-Champaign, Illinois (Drs Horn, Smith), and Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois (Drs Horn, Woods).
出版信息
J Occup Environ Med. 2019 Jul;61(7):617-622. doi: 10.1097/JOM.0000000000001626.
OBJECTIVE
Sudden cardiac events account for 40% to 50% of firefighter line-of-duty deaths. Inflammatory proteins are strong biomarkers of cardiovascular inflammation. The present study investigated the effects of aspirin supplementation on inflammatory biomarkers following firefighting.
METHODS
Using a randomized, placebo-controlled, double-blind crossover design, 24 male firefighters (48.2 ± 5.9 years) were allocated into four conditions: acute (81 mg; single-dose) aspirin and placebo supplementation, and chronic (81 mg; 14 days) aspirin and placebo supplementation. Inflammatory proteins [interleukin (IL)-6, C-reactive protein (CRP), intracellular adhesion molecule (ICAM)-1, P-selectin, matrix metalloproteinase-9 (MMP-9)] and antioxidant potential [total antioxidant capacity (TAC)] were measured pre- and post-structural firefighting drills.
RESULTS
Firefighting activities significantly increased IL-6, MMP-9, and P-Selectin; however, no changes in TAC and ICAM-1 were detected. Neither acute nor chronic aspirin supplementation attenuated this inflammatory response.
CONCLUSION
Firefighting significantly increases inflammatory biomarkers and neither acute nor chronic low-dose aspirin mitigates this response.
目的
突发心脏事件占消防员因公殉职的 40%至 50%。炎症蛋白是心血管炎症的有力生物标志物。本研究调查了消防员灭火后补充阿司匹林对炎症生物标志物的影响。
方法
采用随机、安慰剂对照、双盲交叉设计，将 24 名男性消防员（48.2±5.9 岁）分为四组：急性（81mg；单次剂量）阿司匹林和安慰剂补充组，以及慢性（81mg；14 天）阿司匹林和安慰剂补充组。在结构消防演习前后测量炎症蛋白[白细胞介素（IL）-6、C 反应蛋白（CRP）、细胞间黏附分子（ICAM）-1、P-选择素、基质金属蛋白酶-9（MMP-9）]和抗氧化能力[总抗氧化能力（TAC）]。
结果
消防活动显著增加了 IL-6、MMP-9 和 P-选择素；然而，TAC 和 ICAM-1 没有变化。无论是急性还是慢性低剂量阿司匹林补充都没有减轻这种炎症反应。
结论
消防活动显著增加了炎症生物标志物，急性和慢性低剂量阿司匹林都不能减轻这种反应。
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