Olafiranye Oladipupo, Hostler David, Winger Daniel G, Wang Li, Reis Steven E
The Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Department of Exercise and Nutrition Sciences, SUNY University at Buffalo, Buffalo, NY, USA.
Vasc Med. 2015 Jun;20(3):230-6. doi: 10.1177/1358863X15571447. Epub 2015 May 4.
Peripheral arterial stiffness and endothelial function, which are independent predictors of cardiac events, are abnormal in firefighters. We examined the effects of aspirin on peripheral arterial stiffness and endothelial function in firefighters. Fifty-two firefighters were randomized to receive daily 81 mg aspirin or placebo for 14 days before treadmill exercise in thermal protection clothing, and a single dose of 325 mg aspirin or placebo immediately following exertion. Peripheral arterial augmentation index adjusted for a heart rate of 75 (AI75) and reactive hyperemia index (RHI) were determined immediately before, and 30, 60, and 90 minutes after exertion. Low-dose aspirin was associated with lower AI75 (-15.25±9.25 vs -8.08±10.70, p=0.014) but not RHI. On repeated measures analysis, treatment with low-dose aspirin before, but not single-dose aspirin after exertion, was associated with lower AI75 following exertional heat stress (p=0.018). Low-dose aspirin improved peripheral arterial stiffness and wave reflection but not endothelial function in firefighters.
外周动脉僵硬度和内皮功能是心脏事件的独立预测因素，在消防员中这些指标存在异常。我们研究了阿司匹林对消防员外周动脉僵硬度和内皮功能的影响。52名消防员被随机分为两组，在穿着热防护服进行跑步机运动前14天，一组每天服用81毫克阿司匹林，另一组服用安慰剂；运动后立即分别服用一剂325毫克阿司匹林或安慰剂。在运动前以及运动后30、60和90分钟测定心率为75时的外周动脉增强指数（AI75）和反应性充血指数（RHI）。低剂量阿司匹林与较低的AI75相关（-15.25±9.25对-8.08±10.70，p=0.014），但与RHI无关。在重复测量分析中，运动前服用低剂量阿司匹林而非运动后服用单剂量阿司匹林，与运动热应激后较低的AI75相关（p=0.018）。低剂量阿司匹林改善了消防员的外周动脉僵硬度和波反射，但未改善内皮功能。
