AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.
IUBMB Life. 2019 Jul;71(7):1041-1047. doi: 10.1002/iub.2066. Epub 2019 May 15.
For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)-induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA-induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor-like 2 (Nrf2) and heme oxygenase 1 (HO-1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO-1 pathway, which means it protects the kidney from BPA-induced oxidative injury. © 2019 IUBMB Life, 2019.
对于肾脏疾病的发展,氧化应激(OS)被认为是其中一个风险因素。为了治疗或预防肾脏疾病,使用抗氧化剂可能是一种有希望的治疗方法,因为它们可以延缓或阻止氧化反应和炎症过程。木犀草素(Lut)是一种植物类黄酮,是一种药理学上活跃的成分,通常以糖苷形式存在于基础紫苏叶、青椒、芹菜、种子、金银花和甘菊的花中;它具有抗氧化活性。在这项研究中,我们探讨了木犀草素对双酚 A(BPA)诱导的大鼠肾小管毒性的肾脏保护作用。口服给予木犀草素(100 和 200mg/kg)可减轻 BPA 引起的肾脏、血尿素氮、肌酐和血清尿酸水平的异常。木犀草素治疗可减少 BPA 诱导的炎症介质的产生,包括肿瘤坏死因子-α、白细胞介素 6 和白细胞介素 1β。这与肾脏组织病理学特征的显著改善有关。木犀草素增强了核因子样 2(Nrf2)和血红素加氧酶 1(HO-1)的表达,对 BPA 诱导的氧化应激具有保护作用。本研究的结果表明,木犀草素有很强的清除活性氧物质的特性,并可能降低 BPA 诱导的肾毒性中的脂质过氧化和抑制 DNA 损伤。总之,木犀草素的潜在抗氧化作用可能是因为其对 Nrf2/抗氧化反应元件(ARE)/HO-1 通路的调节作用,这意味着它可以保护肾脏免受 BPA 诱导的氧化损伤。©2019 IUBMB Life,2019。