Leti Maggio Eleonora, Zucca Carlotta, Grande Martina, Carrano Raffaele, Infante Antonio, Bei Riccardo, Lucarini Valeria, De Maio Fernando, Focaccetti Chiara, Palumbo Camilla, Marini Stefano, Ferretti Elisabetta, Cifaldi Loredana, Masuelli Laura, Benvenuto Monica, Bei Roberto
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Medical School, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
J Xenobiot. 2024 Oct 2;14(4):1378-1405. doi: 10.3390/jox14040077.
Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with any hormone action. They are categorized according to origin and use, such as industrial chemicals like polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs), plastics like bisphenol A (BPA), plasticizers like phthalates, pesticides like dichlorodiphenyltrichloroethane (DDT), fungicides like vinclozolin, and pharmaceuticals like diethylstilbestrol (DES). Natural EDCs, such as phytoestrogens, are present in the diet of both humans and animals. Polyphenols are a large group of natural compounds derived from plants and are found in beverages and food. They are grouped based on their chemical structure into flavonoids and nonflavonoids and are reported to have many beneficial effects on health, including, but not limited to, anticancer, antioxidant, and anti-inflammatory effects. Moreover, polyphenols have both pro- and antioxidant characteristics, and due to their antioxidant and anti-inflammatory potential, they presumably have a protective effect against damage induced by EDCs. However, polyphenols may act as EDCs. In this review, we report that polyphenols regulate the activity of EDCs, having both positive and negative effects. Hence, a better understanding of the associations between EDCs and polyphenols will allow the establishment of improved approaches to protect human health from EDCs.
内分泌干扰化学物质（EDCs）是能够干扰任何激素作用的化学物质。它们根据来源和用途进行分类，例如工业化学品如多氯联苯（PCBs）和多溴联苯（PBBs）、塑料如双酚A（BPA）、增塑剂如邻苯二甲酸盐、杀虫剂如二氯二苯三氯乙烷（DDT）、杀菌剂如乙烯菌核利以及药物如己烯雌酚（DES）。天然的内分泌干扰化学物质，如植物雌激素，存在于人类和动物的饮食中。多酚是一大类源自植物的天然化合物，存在于饮料和食物中。它们根据化学结构分为黄酮类和非黄酮类，据报道对健康有许多有益作用，包括但不限于抗癌、抗氧化和抗炎作用。此外，多酚具有促氧化和抗氧化特性，由于其抗氧化和抗炎潜力，它们可能对内分泌干扰化学物质诱导的损伤具有保护作用。然而，多酚可能充当内分泌干扰化学物质。在本综述中，我们报告多酚调节内分泌干扰化学物质的活性，具有正面和负面效应。因此，更好地了解内分泌干扰化学物质与多酚之间的关联将有助于建立更好的方法来保护人类健康免受内分泌干扰化学物质的影响。
