Department of Pediatric Infectious Diseases, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland.
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland.
Eur J Clin Microbiol Infect Dis. 2019 Aug;38(8):1443-1447. doi: 10.1007/s10096-019-03569-0. Epub 2019 May 15.
Biomarkers classically studied in Alzheimer's disease have been analyzed in numerous central nervous system infections in adults, but there are scarce data on these biomarkers in children. Enteroviruses appear to be the most common cause of aseptic meningitis throughout the world. The aim of the study was to investigate neuroinflammatory properties of non-polio enteroviruses by measuring CSF concentrations of biomarkers that are involved in neuropathological pathways of neurodegenerative disorders. We measured Aβ42, t-tau, and S100B concentrations in 42 children with enteroviral meningitis (EM) compared to control group without central nervous system infection. We found enteroviral meningitis (EM) to reduce CSF concentration of Aβ42 (median, 1051.1 pg/mL; interquartile range (IQR), 737.6-1559.5 vs. median, 459.4 pg/mL; IQR, 312.0-662.0, p < 0.001). In contrast, CSF concentrations of t-tau and S100B were not affected by EM. There was a correlation between total neutrophil count in CSF and Aβ42 (R = - 0.59, p < 0.001). Absolute number of mononuclear cells in the CSF correlated with CSF t-tau (R = 0.41, p < 0.05). Both correlations remained significant after adjustment for age, blood leukocytes, serum CRP, CSF leukocytes, and CSF protein concentration.
在许多成人中枢神经系统感染中，经典地研究了阿尔茨海默病的生物标志物，但在儿童中，这些生物标志物的数据很少。肠道病毒似乎是全世界无菌性脑膜炎的最常见原因。本研究的目的是通过测量参与神经退行性疾病神经病理途径的生物标志物的 CSF 浓度，来研究非脊髓灰质炎肠道病毒的神经炎症特性。我们测量了 42 例肠道病毒脑膜炎（EM）患儿和无中枢神经系统感染对照组的 CSF 中 Aβ42、t- tau 和 S100B 的浓度。我们发现肠道病毒脑膜炎（EM）降低了 CSF 中 Aβ42 的浓度（中位数，1051.1 pg/mL；四分位距（IQR），737.6-1559.5 与中位数，459.4 pg/mL；IQR，312.0-662.0，p < 0.001）。相比之下，CSF 中 t- tau 和 S100B 的浓度不受 EM 的影响。CSF 中总中性粒细胞计数与 Aβ42 之间存在相关性（R = -0.59，p < 0.001）。CSF 中单核细胞的绝对数量与 CSF t- tau 相关（R = 0.41，p < 0.05）。在调整年龄、血白细胞、血清 CRP、CSF 白细胞和 CSF 蛋白浓度后，这两种相关性仍然显著。
