De Leonardis Francesco, Novielli Chiara, Giannico Benedetta, Mariggiò Maria Addolorata, Castagnola Elio, Santoro Nicola
Department of Pediatrics, Division of Pediatric Hematology-Oncology.
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari.
J Pediatr Hematol Oncol. 2020 Aug;42(6):e469-e471. doi: 10.1097/MPH.0000000000001508.
Invasive aspergillosis in hematologic pediatric patients is an opportunistic infection that is difficult to treat, with a high mortality rate when localized in the central nervous system. We are describing a 3-year-old girl who was affected by acute lymphoblastic leukemia who developed cerebral and pulmonary aspergillosis during induction chemotherapy. The patient failed first-line voriconazole treatment because of being a CYP2C19 ultrarapid metabolizer and received effective isavuconazole therapy with no notable side effects.
血液系统疾病的儿科患者侵袭性曲霉病是一种难以治疗的机会性感染，当病变局限于中枢神经系统时死亡率很高。我们报告一名3岁患急性淋巴细胞白血病的女孩，在诱导化疗期间发生脑曲霉病和肺曲霉病。该患者因是CYP2C19超快代谢者，一线伏立康唑治疗失败，随后接受了有效的艾沙康唑治疗，且无明显副作用。
