人血小板脂氧合酶和环氧化酶对8,11,14,17-二十碳四烯酸的代谢
Metabolism of 8,11,14,17-eicosatetraenoic acid by human platelet lipoxygenase and cyclooxygenase.
作者信息
Careaga M M, Sprecher H
出版信息
Biochim Biophys Acta. 1987 Jul 13;920(1):94-101. doi: 10.1016/0005-2760(87)90315-8.
Human platelets metabolize 8,11,14,17-eicosatetraenoic acid primarily into 12-hydroxy-8,10,14,17-eicosatetraenoic acid. Several other hydroxy acids were also produced in small amounts via an indomethacin insensitive pathway. Platelet cyclooxygenase metabolized this acid only into 12-hydroxy-8,10,14-heptadecatrienoic acid. It was not possible to detect any cyclic products even though vesicular gland cyclooxygenase metabolizes this (n-3) acid to 17,18-dehydroprostaglandin E1 (Oliw, E.H., Sprecher, H. and Hamberg, M. (1986) J. Biol. Chem. 261, 2675-2683).
人类血小板主要将8,11,14,17-二十碳四烯酸代谢为12-羟基-8,10,14,17-二十碳四烯酸。还通过一条对吲哚美辛不敏感的途径少量生成了其他几种羟基酸。血小板环氧化酶仅将这种酸代谢为12-羟基-8,10,14-十七碳三烯酸。尽管精囊环氧化酶可将这种（n-3）酸代谢为17,18-脱氢前列腺素E1（奥利夫，E.H.，施普雷彻，H.和哈姆贝格，M.（1986年）《生物化学杂志》261卷，2675 - 2683页），但无法检测到任何环状产物。
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