Colenbrander B, Meijer J C, Macdonald A A, van de Wiel D F, Engel B, de Jong F H
Biol Reprod. 1987 May;36(4):871-7. doi: 10.1095/biolreprod36.4.871.
The effect of castration and of administration of charcoal-treated porcine follicular fluid (pFF) containing inhibin-like activity on plasma concentration of gonadotropic hormones was studied in neonatal pigs. Plasma follicle-stimulating hormone (FSH) concentration averaged 25.1 +/- 1.5 ng/ml (mean +/- SEM) in 1-wk-old females and gradually declined to 20.2 +/- 0.7 ng/ml 6 wk later. Ovariectomy did not significantly influence plasma FSH concentration. In males, concentration averaged 8.0 +/- 0.7 ng/ml before castration but rose significantly within 2 days after castration. Injection of luteinizing hormone-releasing hormone (LHRH) did not influence plasma FSH concentrations in intact males, but did in females and in 7-wk-old males castrated at 1 wk. Plasma luteinizing hormone (LH) concentrations in 1-wk-old females (2.2 +/- 0.4 ng/ml) gradually declined and were not influenced by castration. Concentrations of plasma LH in 1-wk-old male piglets (2.8 +/- 0.7 ng/ml) were not significantly influenced by castration within 2 days but were significantly higher 6 wk later. LHRH induced a significant rise in plasma LH concentrations in all animals. Injection of pFF resulted in a decline of plasma FSH concentrations in intact and castrated males and in intact females, but did not influence plasma LH concentrations. These data demonstrate a sex-specific difference in the control of plasma FSH, but not in plasma LH concentration in the neonatal pig. Plasma FSH concentrations, but not plasma LH concentrations, are suppressed by testicular hormones in 1-wk-old piglets. Plasma FSH concentrations can be suppressed in both neonatal male and female pigs by injections of pFF.
在新生仔猪中研究了去势以及注射含抑制素样活性的经活性炭处理的猪卵泡液（pFF）对促性腺激素血浆浓度的影响。1周龄雌性仔猪血浆促卵泡激素（FSH）浓度平均为25.1±1.5 ng/ml（均值±标准误），6周后逐渐降至20.2±0.7 ng/ml。卵巢切除对血浆FSH浓度无显著影响。在雄性仔猪中，去势前FSH浓度平均为8.0±0.7 ng/ml，但去势后2天内显著升高。注射促黄体生成素释放激素（LHRH）对未阉割雄性仔猪的血浆FSH浓度无影响，但对雌性仔猪以及1周龄时去势的7周龄雄性仔猪有影响。1周龄雌性仔猪血浆促黄体生成素（LH）浓度（2.2±0.4 ng/ml）逐渐下降，且不受去势影响。1周龄雄性仔猪血浆LH浓度（2.8±0.7 ng/ml）在2天内去势对其无显著影响，但6周后显著升高。LHRH可使所有动物的血浆LH浓度显著升高。注射pFF导致未阉割和去势雄性以及未阉割雌性仔猪的血浆FSH浓度下降，但对血浆LH浓度无影响。这些数据表明，新生仔猪在血浆FSH调控方面存在性别特异性差异，但血浆LH浓度不存在这种差异。1周龄仔猪的血浆FSH浓度受睾丸激素抑制，而血浆LH浓度不受影响。注射pFF可使新生雄性和雌性仔猪的血浆FSH浓度均受到抑制。
