Jin Zhe, Song Linlin, Zheng Zhenguo, Zhang Shuying, Wang Meilan
Department of Cardiology, the Hunchun Hospital, Jilin.
Department of Cardiology, the Affiliated Xinhua Hospital of Dalian University.
Medicine (Baltimore). 2019 May;98(20):e15633. doi: 10.1097/MD.0000000000015633.
Side-branch occlusion is a serious complication of provisional one-stent strategies used to treat coronary bifurcation lesions. The aim of the study was to compare the short- and long-term clinical outcomes between the balloon-stent kissing technique (BSKT) and jailed wire technique (JWT) in patients with non-left coronary bifurcation lesions.This prospective, double-blinded, randomized controlled study enrolled 89 consecutive patients (aged 18-85 years) with 90 true bifurcation lesions (hemadostenosis ≥70%; bifurcation angle <90°; Medina classification 1.1.1, 1.0.1, or 0.1.1) who underwent percutaneous coronary intervention (PCI) at the Zhongshan Hospital Affiliated to Dalian University (China) between January 2013 and May 2016. The patients were randomly divided into the BSKT (44 patients, 45 lesions) and JWT (45 patients, 45 lesions) groups. The intervention was conducted according to technical requirements using a single-stent strategy. Operative success rate, occurrence of complications, postoperative quantitative coronary angiography, and incidence of perioperative and long-term major adverse cardiovascular events (MACEs) were compared between groups.The intervention success rate was 100% in both groups. After main-branch stenting, the BSKT was associated with significantly lower rates of side-branch occlusion (0% vs 15.6%, P < .05) and side-branch post-processing (8.9% vs 26.7%, P < .05) than the JWT. The BSKT was associated with significantly lower degrees of postoperative proximal main-branch residual stenosis (6.1 ± 5.1% vs 9.6 ± 8.6%, P < .05) and side-branch ostial stenosis (51.6 ± 20.6% vs 70.3 ± 20.8%, P < .05) than the JWT. The incidence of perioperative MACEs was significantly lower in the BSKT group than in the JWT group (0% vs 13.3%, P < .05). Patients were followed for a mean duration of 19.0 ± 6.1 months. The occurrence rates of long-term MACEs, angina of Canadian Cardiovascular Society grade ≥2, and severe heart failure were not significantly different between groups.The BSKT is a safe and effective technique that may have advantages over the JWT with regard to protection of the side-branch during PCI for bifurcation lesions.
边支闭塞是用于治疗冠状动脉分叉病变的临时单支架策略的一种严重并发症。本研究的目的是比较球囊-支架吻合法(BSKT)和拘禁导丝技术(JWT)在非左冠状动脉分叉病变患者中的短期和长期临床结局。这项前瞻性、双盲、随机对照研究纳入了89例连续患者(年龄18 - 85岁),这些患者有90处真性分叉病变(血管狭窄≥70%;分叉角度<90°;Medina分型为1.1.1、1.0.1或0.1.1),于2013年1月至2016年5月在中国大连大学附属中山医院接受经皮冠状动脉介入治疗(PCI)。患者被随机分为BSKT组(44例患者,45处病变)和JWT组(45例患者,45处病变)。采用单支架策略根据技术要求进行干预。比较两组之间的手术成功率、并发症发生率、术后定量冠状动脉造影以及围手术期和长期主要不良心血管事件(MACE)的发生率。两组的干预成功率均为100%。主支支架置入后,与JWT相比,BSKT的边支闭塞率(0%对15.6%,P<0.05)和边支后处理率(8.9%对26.7%,P<0.05)显著更低。与JWT相比,BSKT的术后主支近端残余狭窄程度(6.1±5.1%对9.6±8.6%,P<0.05)和边支开口狭窄程度(51.6±20.6%对70.3±20.8%,P<0.05)显著更低。BSKT组围手术期MACE的发生率显著低于JWT组(0%对13.3%,P<0.05)。患者平均随访19.0±6.1个月。两组之间长期MACE、加拿大心血管学会≥2级心绞痛和严重心力衰竭的发生率无显著差异。对于分叉病变PCI过程中的边支保护,BSKT是一种安全有效的技术,可能优于JWT。