Campione Elena, Dattola Annunziata, Di Prete Monia, Di Paolo Daniele, Ferlosio Amedeo, Orlandi Augusto, Bianchi Luca
Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy.
Department of Anatomic Pathology, University of Rome Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy.
BMC Dermatol. 2019 May 17;19(1):6. doi: 10.1186/s12895-019-0086-4.
We describe a case of leucocytoclasic vasculitis induced by Sofosbuvir and its disappearence after the end of the therapy. The hepatitis C virus, firstly described in 1989, is a major global health problem, with high morbidity and mortality. We observed a temporal relationship between the treatment and the onset of vasculitis. We emphasize the multidisciplinary approach to the patients with liver disease to improve the quality of life of these patients.
A 53-year-old Caucasian man with a history of hepatitis C virus genotype 1 infection was examined at our Department of Dermatology for the occurrence of palpable purpura. The patient referred that the first appearance of the dermatoses was about one month after initiation of therapy with Sofosbuvir for hepatitis C.
Vasculitis appeared after the beginning of Sofosbuvir and, even though it was treated with different medications proved to be effective, it disappeared only after the conclusion of the therapy, giving a strong evidence to be a drug eruption.
我们描述了一例由索磷布韦诱发的白细胞破碎性血管炎病例及其在治疗结束后的消退情况。丙型肝炎病毒于1989年首次被描述，是一个重大的全球健康问题，具有高发病率和死亡率。我们观察到治疗与血管炎发作之间存在时间关系。我们强调对肝病患者采取多学科方法以改善这些患者的生活质量。
一名53岁的白种男性，有丙型肝炎病毒1型感染史，因出现可触及的紫癜而到我们皮肤科就诊。该患者称，在开始使用索磷布韦治疗丙型肝炎约一个月后首次出现皮肤病症状。
血管炎在索磷布韦治疗开始后出现，尽管使用不同药物治疗证明有效，但仅在治疗结束后才消失，有力地证明这是一种药疹。
