Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2019 Dec;234(12):21547-21559. doi: 10.1002/jcp.28781. Epub 2019 May 16.
Asthma is the most common respiratory disease accompanied by lung inflammatory disorders. The main symptoms are airway obstruction, chronic inflammation due to mast cell and eosinophil activity, and the disturbance of immune responses mostly mediated by the Th2 response. Genetic background and environmental factors also contribute to the pathogenesis of asthma. Today, microRNAs (miRNAs) are known as remarkable regulators of gene expression. As a small group of noncoding single-strand RNAs, mature miRNAs (~21 nucleotides) modulate the gene expression by targeting complement RNAs at both transcriptional and posttranscriptional levels. The role of miRNAs in the pathogenesis of many diseases such as allergies, asthma, and autoimmunity has been vastly studied. This review provides a thorough research update on the role of miRNAs in the pathogenesis of asthma and their probable role as diagnostic and/or therapeutic biomarkers.
哮喘是最常见的呼吸道疾病，伴有肺部炎症性疾病。其主要症状是气道阻塞、肥大细胞和嗜酸性粒细胞活性引起的慢性炎症，以及主要由 Th2 反应介导的免疫反应紊乱。遗传背景和环境因素也促成了哮喘的发病机制。如今，微 RNA（miRNA）被认为是基因表达的重要调控因子。作为一小群非编码单链 RNA，成熟的 miRNA（~21 个核苷酸）通过靶向转录和转录后水平的互补 RNA 来调节基因表达。miRNA 在过敏、哮喘和自身免疫等许多疾病的发病机制中的作用已经得到了广泛的研究。本综述提供了关于 miRNA 在哮喘发病机制中的作用及其作为诊断和/或治疗生物标志物的可能作用的全面研究更新。
