Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia, Australia.
Rev Med Virol. 2019 Jul;29(4):e2037. doi: 10.1002/rmv.2037. Epub 2019 May 16.
Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulating dengue viruses (DENV) in Indonesia between 1973 and 2016. This was conducted through a systematic review of the literature and phylogenetic analysis of available DENV sequences. Available data from National Disease Surveillance System have indicated an increasing trend of dengue incidence in Indonesia over the past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6 to 8 years. In contrast, the case fatality rate has decreased approximately by half with each decade since 1980. Over this 50-year time span, serotype shifts, genotype displacement within DENV-1 and DENV-2, and introduction of DENV-1 and DENV-3 genotype from other countries occurred. These events were associated with increased incidence of dengue cases. Our study also provides a valuable national snapshot of DENV genetic diversity in Indonesia that may contribute to development of more effective dengue vaccine compositions for the region.
尽管印度尼西亚的几个主要城市都有流行病学和分子流行病学（血清型、基因型和谱系信息）数据，但目前还没有对印度尼西亚随时间推移的登革热进行全面的国家研究。本研究旨在提供印度尼西亚 1973 年至 2016 年间循环登革热病毒 (DENV) 的综合流行病学情况。这是通过对现有 DENV 序列的文献系统回顾和系统发育分析来完成的。国家疾病监测系统的现有数据表明，印度尼西亚过去 50 年来登革热发病率呈上升趋势。发病率似乎呈周期性，大约每 6 到 8 年达到峰值。相比之下，自 1980 年以来，每十年病死率下降了约一半。在这 50 年的时间里，血清型转变、DENV-1 和 DENV-2 中的基因型取代以及来自其他国家的 DENV-1 和 DENV-3 基因型的引入都发生了。这些事件与登革热病例发病率的增加有关。我们的研究还提供了印度尼西亚 DENV 遗传多样性的宝贵国家快照，这可能有助于为该地区开发更有效的登革热疫苗成分。
