Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicinee, Seoul, Korea.
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Endocrinol Metab (Seoul). 2019 Jun;34(2):169-178. doi: 10.3803/EnM.2019.34.2.169. Epub 2019 May 15.
To evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.
The data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (CNB) was performed on 16 benign thyroid nodules previously treated using RFA. The parameters of the patients were compared, between the time of enrollment and the last follow-up examination, using linear mixed model statistical analysis.
No atypical cells or neoplastic transformation were detected in the undertreated peripheral portion of treated benign nodules on the CNB specimen. RFA altered neither the thyroid capsule nor the thyroid tissue adjacent to the treated area. On histopathological examinations, we observed 81.2% acellular hyalinization, which was the most common finding. After a mean follow-up period of over 5 years, the mean volume of thyroid nodule had decreased to 6.4±4.2 mL, with a reduction rate of 81.3%±5.8% (<0.0001).
RFA is a technically feasible treatment method for benign thyroid nodules, with no carcinogenic effect or tissue damage of the normal thyroid tissue adjacent to the RFA-treated zone.
评估射频消融（RFA）治疗良性甲状腺结节并通过活检进行细胞形态学改变以及任何恶性转化的临床可行性。
数据回顾性收集于 2008 年 4 月至 2013 年 6 月之间，对之前接受 RFA 治疗的 16 个良性甲状腺结节进行了核心针活检（CNB）。使用线性混合模型统计分析比较患者在入组时和最后随访检查时的参数。
在 CNB 标本中，未在治疗后良性结节的未处理外周部分检测到非典型细胞或肿瘤性转化。RFA 既不改变甲状腺包膜，也不改变治疗区域附近的甲状腺组织。在组织病理学检查中，我们观察到 81.2%的无细胞性玻璃样变性，这是最常见的发现。平均随访 5 年以上后，甲状腺结节的平均体积减少至 6.4±4.2 mL，减少率为 81.3%±5.8%（<0.0001）。
RFA 是治疗良性甲状腺结节的一种可行的技术方法，不会对 RFA 治疗区域附近的正常甲状腺组织产生致癌作用或组织损伤。
