a Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy , Ain Shams University , Cairo , Egypt.
J Microencapsul. 2019 May;36(3):250-266. doi: 10.1080/02652048.2019.1620355. Epub 2019 Jun 7.
Lavender oil consists of around 100 components and is susceptible to volatilisation and degradation reactions. Microencapsulate lavender oil by spray drying using a biocompatible polymeric blend of gum acacia and maltodextrin to protect the oil components. Effect of total polymer content, oil loading, gum acacia, and maltodextrin proportions on the size, yield, loading, and encapsulation efficiency of the microparticles was investigated. Morphology and oil localisation within microparticles were assessed by confocal laser scanning electron microscope. Structural preservation and compatibility were assessed using Fourier transform infra-red spectroscopy, differential scanning calorimetry, and gas chromatography-mass spectrometry. Lavender microparticles of size 12.42 ± 1.79 µm prepared at 30 w/w% polymer concentration, 16.67 w/w% oil loading, and 25w/w% gum acacia showed maximum oil protection at high loading (12 mg w/w%), and encapsulation efficiency (77.89 w/w%). Lavender oil was successfully microencapsulated into stable microparticles by spray drying using gum acacia/maltodextrin polymeric blend.
薰衣草油由大约 100 种成分组成,容易发生挥发和降解反应。通过喷雾干燥使用生物相容性的阿拉伯胶和麦芽糊精聚合物混合物来微封装薰衣草油,以保护油成分。考察了总聚合物含量、油负载量、阿拉伯胶和麦芽糊精比例对微颗粒的大小、产率、负载量和包封效率的影响。通过共焦激光扫描电子显微镜评估微颗粒的形态和油的定位。使用傅里叶变换红外光谱、差示扫描量热法和气相色谱-质谱法评估结构保存和相容性。在聚合物浓度为 30w/w%、油负载量为 16.67w/w%和 25w/w%阿拉伯胶的条件下制备的粒径为 12.42±1.79μm 的薰衣草微颗粒,在高负载量(12mg w/w%)和包封效率(77.89w/w%)下表现出最大的油保护作用。通过使用阿拉伯胶/麦芽糊精聚合物混合物的喷雾干燥成功地将薰衣草油微封装到稳定的微颗粒中。