Laakso M L, Johansson G G, Porkka-Heiskanen T
Exp Gerontol. 1987;22(1):37-46. doi: 10.1016/0531-5565(87)90013-1.
It has been suggested that the decreased plasma levels of FSH and LH, often found in old male rats, are due to a diminished adenohypophyseal capacity to secrete the hormones and/or by changes in the hypothalamic regulatory system. We studied the effect of varying lighting conditions (12/12 h LD, continuous light and continuous darkness) on the plasma levels of the gonadotropins in castrated young adult and old male rats. We expected the sensitivity of the regulatory system to light to decrease or disappear with aging. The results for FSH supported this hypothesis: the plasma levels of FSH were more stable to changes of lighting conditions in the old rats. In disagreement with our hypothesis, the levels of LH were more sensitive to light changes in old than in young rats. It was concluded that the regulatory systems of the two hormones vary differently with age.
有人提出，老年雄性大鼠中经常发现的促卵泡激素（FSH）和促黄体生成素（LH）血浆水平降低，是由于腺垂体分泌这些激素的能力下降和/或下丘脑调节系统发生了变化。我们研究了不同光照条件（12/12小时光照/黑暗、持续光照和持续黑暗）对去势成年雄性幼鼠和老年雄性大鼠促性腺激素血浆水平的影响。我们预期调节系统对光的敏感性会随着衰老而降低或消失。FSH的结果支持了这一假设：老年大鼠中FSH的血浆水平对光照条件变化更稳定。与我们的假设不同的是，老年大鼠中LH的水平比幼年大鼠对光照变化更敏感。得出的结论是，这两种激素的调节系统随年龄变化的方式不同。
