Zhang Gao-Peng, Huang Shuai, Jiang Yang-Jie, Liu Xiu-Yan, Ding Chang-Hua, Wei Yin, Hou Xue-Long
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (SIOC), China.
Chem Commun (Camb). 2019 May 30;55(45):6449-6452. doi: 10.1039/c9cc01960j.
A highly efficient catalyst for Pd-catalyzed cyclopropanation was developed using a bulkier N-heterocyclic carbene ligand, with which the nitriles reacted with mono substituted allyl reagents to afford cyclopropanes in high yields with high cyclopropanation/allylation and enantioselectivities. The reasons for cyclopropanation were investigated and the usefulness of the products was demonstrated.
使用一种位阻更大的N-杂环卡宾配体开发了一种用于钯催化环丙烷化反应的高效催化剂，腈类与单取代烯丙基试剂通过该催化剂反应，能够以高环丙烷化/烯丙基化及对映选择性高产率地得到环丙烷。对环丙烷化反应的原因进行了研究，并证明了产物的实用性。
