Slenter Inge J M, Djajadiningrat-Laanen Sylvia C, Elders Daphne J, de Gee Reinoud, Koele Linda E, Vermeer Loes W, Boevé Michael H
Ophthalmology Section, Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands.
Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Vet Ophthalmol. 2020 Jan;23(1):16-24. doi: 10.1111/vop.12679. Epub 2019 May 17.
To investigate the effects of topical dorzolamide 2% q8h and brinzolamide 1% q8h, administered either alone (A and B, respectively) or in combination with topical timolol 0.5% q12h (C and D, respectively), on the circadian pattern of intraocular pressure (IOP), the pupil size, and heart rate in healthy cats.
In this prospective, randomized, double-blinded study, 10 healthy, adult cats were randomly assigned to one of four groups and the eye to be medicated was randomly assigned. IOP, pupil diameter, and heart rate were measured at 3-hour intervals. A 5 days' adjustment period was followed by a 5 days' placebo (baseline) period. Then, all groups of cats received all four treatments (A-D) according to a Latin square-based rotating schedule. Five days' medication periods were alternated with 3 days' washout periods.
Mean baseline IOP was 13.6 ± 2.7 mm Hg. All treatments resulted in a statistically significant decrease in mean IOP in the treated eye: A: -2.33 mm Hg (95% CI: -2.71, -1.94), B: -1.91 mm Hg (95% CI: -2.30, -1.53), C: -2.36 mm Hg (95% CI: -2.74, -1.97), and D: -2.37 mm Hg (95% CI: -2.76, -1.98) and the nontreated eye: A: -0.19 mm Hg (95% CI: -0.28, -0.11), B: -0.18 mm Hg (95% CI: -0.27, -0.10), C -0.31 mm Hg (95% CI: -0.40, -0.23), and D: -0.24 mm Hg (95% CI: -0.32, -0.15). Timolol resulted in an additional, significant decrease in IOP of 4% and 5%, respectively, compared to A and B, and in mild bradycardia and miosis.
Topical administration of dorzolamide 2% and brinzolamide 1% q8h significantly decreased IOP in healthy cats. Supplemental timolol 0.5% eye drops q12h resulted in an additional, statistically significant reduction of IOP.
研究每8小时一次局部使用2%多佐胺和每8小时一次局部使用1%布林佐胺单独给药（分别为A和B组）或与每12小时一次局部使用0.5%噻吗洛尔联合给药（分别为C和D组）对健康猫眼压昼夜变化模式、瞳孔大小和心率的影响。
在这项前瞻性、随机、双盲研究中，10只健康成年猫被随机分配到四组之一，且随机分配用药眼。每隔3小时测量眼压、瞳孔直径和心率。先有5天的调整期，随后是5天的安慰剂（基线）期。然后，所有猫组根据基于拉丁方的轮换方案接受所有四种治疗（A - D）。5天的用药期与3天的洗脱期交替进行。
平均基线眼压为13.6±2.7毫米汞柱。所有治疗均使治疗眼的平均眼压有统计学意义地降低：A组：-2.33毫米汞柱（95%置信区间：-2.71，-1.94），B组：-1.91毫米汞柱（95%置信区间：-2.30，-1.53），C组：-2.36毫米汞柱（95%置信区间：-2.74，-1.97），D组：-2.37毫米汞柱（95%置信区间：-2.76，-1.98）；未治疗眼：A组：-0.19毫米汞柱（95%置信区间：-0.28，-0.11），B组：-0.18毫米汞柱（95%置信区间：-0.27，-0.10），C组：-0.31毫米汞柱（95%置信区间：-0.40, -0.23），D组：-0.24毫米汞柱（95%置信区间：-0.32，-0.15）。与A组和B组相比，噻吗洛尔分别使眼压额外显著降低4%和5%，并导致轻度心动过缓和瞳孔缩小。
每8小时一次局部使用2%多佐胺和1%布林佐胺可显著降低健康猫的眼压。每12小时一次补充0.5%噻吗洛尔滴眼液可使眼压在统计学上进一步显著降低。
