Schulte K, Singer M V, Eysselein V, Demol P, Goebell H
Digestion. 1987;36(3):162-7. doi: 10.1159/000199413.
The effects of rioprostil (a newly developed synthetic prostaglandin E1 analogue) on meal-stimulated gastric acid secretion was evaluated in 8 healthy human volunteers. Gastric acid output was measured by intragastric titration on 4 different occasions. The following procedure was invariably employed: after a basal period of 45 min, 5 peptone meals (8%, 500 ml each) were given intragastrically in 45-min intervals and gastric acid output was measured continuously. 45 min after the first meal, either placebo or 150, 300 or 600 micrograms of rioprostil were given intragastrically in a randomized order and on different days. 15 min later, the second meal was given and intragastric titration continued. Rioprostil caused a dose-dependent inhibition of the 3-hour integrated gastric acid response to the peptone meals. The percentage of inhibition was 41, 68 and 79%, respectively, for 150, 300 and 600 micrograms of rioprostil. Whereas the inhibition by the two highest doses was statistically significant, this was not the case for the lowest dose of rioprostil. The integrated 3-hour plasma gastrin response to the peptone meals was not significantly changed by any of the doses of rioprostil. No significant adverse effects were observed with rioprostil.
在8名健康志愿者中评估了利奥前列素（一种新开发的合成前列腺素E1类似物）对进餐刺激的胃酸分泌的影响。通过胃内滴定法在4种不同情况下测量胃酸分泌量。始终采用以下程序：在45分钟的基础期后，每隔45分钟胃内给予5次蛋白胨餐（每次8%，500毫升），并持续测量胃酸分泌量。在第一餐45分钟后，以随机顺序且在不同日期胃内给予安慰剂或150、300或600微克利奥前列素。15分钟后，给予第二餐并继续进行胃内滴定。利奥前列素对蛋白胨餐引起的3小时胃酸综合反应产生剂量依赖性抑制。对于150、300和600微克利奥前列素，抑制百分比分别为41%、68%和79%。虽然两个最高剂量的抑制作用具有统计学意义，但最低剂量的利奥前列素并非如此。利奥前列素的任何剂量对蛋白胨餐引起的3小时血浆胃泌素综合反应均无显著改变。未观察到利奥前列素有明显的不良反应。
