一种新型的银屑病关节炎疾病影响（PsAID）问卷的作用。

A novel role for the psoriatic arthritis impact of disease (PsAID) questionnaire.

机构信息

Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.

出版信息

Semin Arthritis Rheum. 2019 Oct;49(2):241-245. doi: 10.1016/j.semarthrit.2019.04.001. Epub 2019 Apr 19.

DOI:10.1016/j.semarthrit.2019.04.001

PMID:31101369

Abstract

BACKGROUND

The Minimal Disease Activity (MDA) uses the Health Assessment Questionnaire (HAQ) as one criterion. HAQ does not correlate well with disease activity with increased PsA disease duration, and its use in the MDA has been questioned. The Psoriatic Arthritis Impact of Disease (PsAID) was specifically developed for PsA Patients. We aimed to validate the PsAID within our patient cohort and determine if the PsAID can replace the HAQ in the MDA.

METHODS

Patients were recruited from the PsA clinic and assessed according to a standard protocol including demographics, clinical features and laboratory tests. Descriptive statistics were calculated. PsAID cut-offs for use in the MDA were generated based on the Clinical Disease Activity for Psoriatic Arthritis (cDAPSA).

RESULTS

115 patients completed the PsAID. There were 70 males, 45 females, with a mean PsA duration of 18.7 (±11.6) years. Mean scores of PsAID-9 and PsAID-12 were 3.4 (±2.4) and 3.2 (±2.3), respectively. The PsAID correlated moderately well with 9 of the PROMs administered in the clinic (ρ = 0.51-0.78). Four PsAID cutoffs based on cDAPSA were generated for use in the MDA: remission (REM) PsAID-9, REM PsAID-12, low disease activity (LDA) PsAID-9, and LDA PsAID-12. All four versions of the PsAID MDAs had sensitivity greater than 85% with the HAQ-MDA, and three versions of the PsAID-MDA had specificity greater than 85% with the HAQ-MDA.

CONCLUSIONS

The high sensitivity and specificity of the PsAID-MDA with the HAQ-MDA suggest that the PsAID is an effective replacement for the HAQ in the MDA.

摘要

背景

最小疾病活动度（MDA）使用健康评估问卷（HAQ）作为一个标准。HAQ 与疾病活动度相关性较差，尤其是在银屑病关节炎（PsA）疾病持续时间增加的情况下，其在 MDA 中的应用受到质疑。银屑病关节炎影响疾病（PsAID）是专门为 PsA 患者开发的。我们旨在验证该量表在我们的患者队列中的有效性，并确定 PsAID 是否可以替代 MDA 中的 HAQ。

方法

从 PsA 诊所招募患者，并根据标准方案进行评估，包括人口统计学、临床特征和实验室检查。计算描述性统计数据。根据银屑病关节炎的临床疾病活动度（cDAPSA），生成用于 MDA 的 PsAID 切点。

结果

115 例患者完成了 PsAID。其中 70 例为男性，45 例为女性，PsA 病程平均为 18.7（±11.6）年。PsAID-9 和 PsAID-12 的平均得分分别为 3.4（±2.4）和 3.2（±2.3）。PsAID 与诊所中 9 种 PROMs 中度相关（ρ=0.51-0.78）。根据 cDAPSA 生成了用于 MDA 的 4 个 PsAID 切点：缓解（REM）PsAID-9、REM PsAID-12、低疾病活动度（LDA）PsAID-9 和 LDA PsAID-12。与 HAQ-MDA 相比，所有四种版本的 PsAID-MDA 的敏感性均大于 85%，其中三种版本的 PsAID-MDA 的特异性均大于 85%。