Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clin Pharmacol Ther. 2019 Sep;106(3):501-504. doi: 10.1002/cpt.1505. Epub 2019 Jul 1.
Predicting drug interactions, disposition, and side effects is central to the practice of clinical pharmacology. Until recently, the human microbiome has been an under-appreciated player in the dynamics of drug metabolism. It is now clear that humans are “superorganisms” with about 10-fold more microbial cells than human cells and harboring an immense diversity of microbial enzymes. Owing to the advent of new technologies, we are beginning to understand the human microbiome’s impact on clinical pharmacology.
预测药物相互作用、药物处置和药物副作用是临床药理学实践的核心。直到最近,人类微生物组一直是药物代谢动力学中一个被低估的因素。现在很清楚的是,人类是“超级生物体”,其微生物细胞数量是人类细胞的 10 倍之多,并且拥有大量不同的微生物酶。由于新技术的出现,我们开始了解人类微生物组对临床药理学的影响。